I went to the safe and tried the two easiest ones to reach with a HOT. The first was a 12 gauge Longrange, and I could not get the safety to work after firing the first shot. The second was a 12 gauge Specialty, and that one worked. When I get more time, I will try a few others and see what they do, but I'm not worried if they don't.
Like Bill Murphy stated, why would this bother you? If you fired one barrel, I don't see the need to put the safety OFF, I would just open the gun and put a new shell in.