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Is this her first handgun? Does she have any shooting experience?

To simplify this, she wants something that is both reliable and effective in a self-defense role. Small enough to carry but large enough that the recoil isn't overwhelming. Firearms that are not comfortable and pleasant to fire tend to not get enough practice time at the range. And regular practice is key. You cannot just simply purchase a firearm and throw it in a drawer or purse and think it is going to help you when the shit hits the fan. You have to practice and train.

My first thoughts are a Smith and Wesson Bodyguard 2.0 in .380. .380 is a perfectly fine defensive round if you use good defensive ammunition. Don't be intimidated by all the different variants. They can admittedly be a little overwhelming. https://www.smith-wesson.com/products/bodyguard-2