https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504698/
Looking at the NPA candidate gene for A trait, here a study in Chile supports the NPA empiric conclusion that A- trait patients seem more prone to Parkinson's (especially at an early age) .
“Thereby, dopaminergic signalling mediated by low-affinity dopamine receptors is favoured in the nigrostriatal pathway of healthy individuals, whilst the selective stimulation of high-affinity dopamine receptors is promoted in PD.”
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