Here is a recent study that links coronary artery disease with the COMT gene (rs4680/met), a candidate allele for A− trait:
We say “a candidate” because there could well exist several genes other than COMT that give rise to expression of the A− trait by epistasis.
There are also some studies that link coronary disease to the HLA region on chromosome 6.
In Parkinson’s disease (PD), an association of PD with COMT has not been shown in the preponderance of studies. However, PD has been shown to be related to rs2395163 (link below)… which happens to be one of HLA-associated genes that was considered in the study from Finland noted in our previous thread on antisocial disorder. Also, the abstract below also adds to the growing consensus that it is not the HLA genes themselves that are important in behavior, but rather other genes that are hitchhiking along in linkage disequilibrium.
So, according to the NPA model, a posited A locus on chromosome 6 could underlie both 1) the non-sanguine A/PA types associated with antisocial disorder, and 2) the A/A− trait associated with coronary disease and PD.
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