So it may be that high metabolism of the major neurotransmitters and thus lower quantities of them may predispose to less neurotransmission. In the instinctual brain this results in less emotionality and in the higher brain centers in causes more creative and sometimes upsetting thought processes. Thus such behaviors as callous and bizarre behavior. The reverse would be perhaps more anxious and depressed behaviors.
Here women with high MAOA showed more emotional instabiity. The authors cite other studies where males showed opposite findings.
This may be a reflection of the position of MAOA gene on the X chromosome such that males have a strong tendancy statistically to have lower MAOA production because they have lower MAOA gene, having only one copy. There is some complexity here where inactivation of one X chromosome in each cell of females may make this a less valid argument according to some authors.
So the explanation may be that the golden mean is the ideal and too high or too low levels of neurotransmitter create atypical behaviors and feelings. So the male (having normally fairly low MAOA levels) with extremely low MAOA and very high neurotransmitters would be in as bad a spot as the female (having normally fairly high MAOA levels) with extremely high MAOA and very low neurotransmitters. At least that is what the consensus of research shows in regard to MAOA. And it actually shows that in males or females in COMT research and behavior.
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