Maybe catecholemine chemistry in the brain is simpler than we think: Ups are anxiety, opioid addiction, bipolar, cancer, etc. and caused by low dopamine
Downs are depression,add, autism, schizophrenia and caused by high dopamine.
Anyway, I think we are wrong in trying to make it all too complicated. There has to be some principles we can follow through the maze. And that's what NPA theory tries to do?