1. The habitancy where the study is performed: A Punctilious habitancy would be a poor choice, since both the study group and the control group would have a high frequency of subjects lacking trait A. This restriction could occur even if traits A and N were not entangled.*
2. Possible entanglement of the lack of trait A with the presence of trait N. But this effect should likewise be negligible for a Punctilious habitancy, and there would be little risk that the study would erroneously conclude that the Condition was related to high frequency of trait N in the Case group.
3. Unintentional difference in the distribution of NPA types between the case and control groups. If the Condition is related to lack of trait A, then a possible (unintentional) difference in the frequency of the NPA types could muddy the waters: either depressing or accentuating the effect of (the lack of) trait A, or by entraining other rogue genes related to NPA personality type.
4. The role of A− trait: As a phenotype, or in a personality test, individuals with the A− trait would correlate with “non-aggression”, but according to the model, the genotype at the A locus could very well be the same as NA or NPA+ individuals with fully expressed A trait.
• See for example Table 12 in the Monograph, where there is no entanglement of trait P, but the results are highly dependent on habitancy type.
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