Been a few years since I was there last, but one of my favourite cities.
The beer is unbelievable obviously- pilsner urquell when in top condition is unbeatable, but theres all kinds of great beer halls and craft beer places.
Youve got everything food wise from the old school goulash and dumpling places to top quality michelin starred places and everything in between, its hard to go wrong really (but stay out of the tourist traps round Wenceles Square etc...)