I would give a sizeable amount of it to my niece and her family.

I would also make large donations to the charities I make very small donations to now.

I would try to find a specialist who could repair my knees. I'm not a good candidate for knee replacements due to having fibromyalgia, but hopefully a specialist would be able to do something else (cartilage replacement?) that would help me walk better.

I would buy a brand new car and new clothes in a smaller size. I need a new wardrobe since I have lost so much weight. I would also get a more comfortable bed and new living room furniture.

Then invest the rest where I would receive a nice sized monthly income from the investments.