Don't get me wrong, I do stand out. In fact, I stand out quite well. Specifically pertaining to letters though and not the overall application, how is it detrimental? I already have asked two anesthesiologists and was contemplating between my employer/supervisor, who knows me well and knows my work ethic, or a chemistry professor who knows who I am, but doesn't know me. It would seem like the logical choice for the employer, right?