Harvard University was founded before calculus was invented. Established in 1636, Harvard is the oldest institution of higher education in the U.S. The “New College,” as it was originally called, had no calculus classes because it didn't exist yet.
The invention of calculus would come in the late 17th century with Gottfried Leibniz’s 1684 publication of “Nova Methodus,” and in part with Isaac Newton’s “Principia” in 1687, followed by additional explanations and reformulations by subsequent mathematicians. Also, European physicist, mathematician and astronomer Galileo was still alive during Harvard’s early years — he died in 1642.