I started Prolia in February (one injection every 6 months) and I have not had any adverse reaction so far. I went to the dentist the other day and he says I may not be a candidate for dental implants while on Prolia. But the Arimidex that I took for 5 years sucked the life out of my bones so what can ya do? I will continue with the Prolia to see if it helps. I took Fosomax for 5 years and it didn’t do me any good at all. The endocrinologist says that Prolia not only helps osteoporosis but it also decreases the risk of bone cancer. So it’s a win win with the exception of dental issues. But I can always wear dentures I guess LOL.