No drug helped me and my bone pain was excruciating. I had it in my lower back, thighs and even my sternum. The only thing that helped ease my pain was heat. Hot baths or heating pad. The second shot that I gave myself (because I am a nurse and I was able to inject it myself) was by far the worst in the series. After that it was painful but not as bad. I believe everyone is very different. What works for some will not work for others. Good luck to you. I hope you find something that works for you.