https://onlinelibrary.wiley.com/doi/full/10.1111/j.1538-7836.2012.04881.x
in which author states that major discoveries come from shrewd observations, sometimes in only one patient or a handful of patients. This is by no means restricted to research in thrombosis, but essentially true in all medical research.
This is encouraging for those of us working on NPA personality theory since we don't have the causative genes identified nor a validated way to sort out patients by NPA group, yet
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