In the search for NPA genes, we have yet to find a satisfactory candidate gene for N trait. One clue may be the role of high parasympathetic /sympathetic ratio in normal sleep function so that genes that promote this could be good candidate genes for N trait. DRD2 is a good one, and DBH is a good one. In office patients, I have noted all patients with narcolepsy seem to have N/NA=/NPA-/NPA= tendancies and definitely no unbridled NA/NPA=, etc. trait, Those with sleep apnea are very similar.
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