Of interest is how the gene is expressed in the absence of A− trait. It could still be expressed in behavior in some subtle way. In the past we posited that it could be expressed as eczema or a predisposition to schizophrenia in N or NP types. Thus, in some families eczema could be a marker for a carrier of a predisposition to schizophrenia.
I am not sure what “novelty-seeking” is actually reflecting, or how different NPA types – and in particular, non-sanguine types -- would respond to questions that presume to assess this feature of behavior. Apparently, novelty-seeking reflects some kind of composite behavior that reflects the expression of a combination of the three NPA traits.
An analogy would be a parable in which in the “Land of Red, Blue and Green” a wandering individual stumbles upon the color Purple. Everyone is amazed, and they think that they have found something “new”, until an assistant professor of physics at the local university points out that Purple is just a combination of Red, Blue and Green.
South Africa, we thought, was rather polymorphic, so it could be that the sample in the study had significant A trait.
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