NPA personality theory
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The physiologic basis for high or low temperament is not knowm... and apparently this concept of temperament is not very popular. I would guess that temperament in the Pavlovian sense (the general activity or reactivity of an individual) is the sum of several -- or many -- genes that are not directly related to the NPA genes. I would guess that they are not related the sympathetic (adrenaline) system either, but it's bound to be very complex.