During the early film noir years there was, I believe, the first noir animation series: Superman.
[url=https://en.wikipedia.org/wiki/Superman_(1940s_animated_film_series)]https://en.wikipedia.org/wiki/Superman_(1940s_animated_film_series)
The one cited in the "50 greatest cartoons" is The Mechanical Monsters.
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If you want to dip deeper:
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