Posted by MERM on 5/26/2009, 11:04 am, in reply to "Ashok Gupta Explains the Amygdala Retraining Program for ME/CFS/FM"
SYMPTOMS AND SECONDARY ILLNESS CYCLES
Hyper-arousal of the body then causes the symptoms (6) and creates Secondary Illness Cycles (7).
Over-stimulation can cause adaptation in receptors so that systems are down-regulated, or certain systems may simply exhaust due to over-stimulation, as is the case with the adrenal glands. Nitric oxide levels may rise (as per the observations of Professor Martin Pall), which can cause a whole host of secondary effects and symptoms in the body, including mitochondria dysfunction, perpetuating the entire vicious circle. Because the immune system is responding inappropriately, opportunistic viruses such as HHV-6 have the opportunity to flourish, increasing symptoms.
Finally, at 7, secondary illnesses such as allergies and chemical sensitivities can occur due to the hypersensitivity of the entire system.
Where I differ from Professor Martin Pall’s Nitric Oxide hypothesis of ME/CFS and other “unexplained" illnesses is that in his NO/ONOO- hypothesis, the Nitric Oxide effects are mainly local.
• I do not believe that this could explain such a pervasive illness with such wide-ranging symptoms.
• Instead, I believe that the Nitric Oxide theory reflects yet another secondary illness cycle rather than the underlying cause of the condition.
Sympathetic over-activity means that sleep rhythms are affected, so the restorative “delta” sleep required for bodily repair is not effective. This has also been shown in Post Traumatic Stress Disorder, an illness where the amygdala has also been heavily implicated. This causes a patient to feel unrefreshed the next morning, causing severe exhaustion, and contributing to pain in fibromyalgia.
PERPETUATING FACTORS
These symptoms are detected by the sensory thalamus/cortex and the insula cortex - the parts of the brain that receive incoming information from the senses (8).
And to complete the cycle, incoming signals are magnified by the amygdala, which keeps the brain and nervous system in a state of hyper arousal. (9)
• The insula may be involved in interpreting the emotional meaning of the symptoms, and passing that representation on to the amygdala.
• At 9, the amygdala is traumatized by any symptoms that it detects in the body, and instantly re-stimulates bodily systems at 4 again.
Note that this central nervous system sensitivity (and resultant abnormal sensory processing causing heightened pain awareness) is gradually becoming a more accepted hypothetical model in fibromyalgia. This then perpetuates into the vicious circle as in the diagram.
FACTORS DETERMINING SYMPTOMS & SEVERITY
If the circle becomes particularly vicious, a patient can become bed-bound. If the cycle is milder, the patient may be able to function to a varying degree. The symptoms in each patient will depend on three factors:
• The severity of the conditioning effects in the amygdala and associated brain structures.
• The specificity of the conditioning; that is, what symptoms and what reactions were going on in the body at the time of the original trauma.
• The specific timing of the trauma – although symptoms can change over time.
Due to the secondary effects of the condition on the body, food intolerances can develop, as well as general sensitivities. This is because when the brain and body are on high alert, the amygdala (in association with other brain structures) is prone to learning new responses to stimuli it would not normally care about.
When the sympathetic system is aroused, digestive and detoxification systems are turned down or switched off, which may explain why many patients complain of feeling “toxic” inside.
A patient will also find that stress can exacerbate the symptoms - simply because it “speeds up” the vicious circle, and the body does not have sufficient resources to deal with that stress. The stress can be mental, emotional or physical.
With some patients, the conditioning effects are not particularly severe, which is why some patients seem to regain their health through general changes in lifestyle. For others, the conditioning in the brain is severe and causes chronic long term illness.
RETRAINING THE AMYGDALA – BASIC CONCEPTS
I wish to emphasize that I believe ME/CFS, fibromyalgia and MCS are real physical conditions, and are in no way psychological. The sensitivity conditioning mainly occurs unconsciously.
As I indicated above, Gulf War Syndrome may represent a combination of all three illnesses to varying degrees, as at the time there was exposure to immunizations, toxins, and physiological stresses all at the same time.
Currently, I do not believe that there are any pharmaceuticals which could target such a specific reaction in the brain. Most pharmaceuticals or supplements target the symptoms rather than the underlying cause. If the conditioning effects are mild, successful treatment of symptoms may bring full recovery, but in the majority of cases, this will probably not occur.
The unconscious brain reaction involved in amygdala dysfunction is not normally under a patient’s control, but I believe that some novel “brain retraining” techniques derived from NLP (Neuro-Linguistic Programming), breathing, meditation techniques, and others, can target the reaction and control the amygdala. The techniques are highly specialized, and do not fit under any one category, which is why I refer to them as "Amygdala Retraining Techniques."
Luckily the amygdala constantly communicates with other parts of the brain, and that’s where retraining can take place.
In animal models, it is understood that the amygdala can be controlled with new neurons being formed, connecting from the pre-frontal cortex to the amygdala, to subdue and control its reactions.
• Some studies have shown that patients with ME/CFS have lower grey matter volume in this part of the brain (pre-frontal cortex).
• Other studies have shown that regular meditation can increase the volume of this part of the brain, showing that “brain” exercises can alter the structure of the brain.
All the Amygdala Retraining techniques are now available as an interactive DVD recovery programme.** I found that most patients could not afford to come to the clinic for treatment, so I wanted to create something that was affordable and easy to use at home.
PILOT RESULTS TO DATE
I recently conducted an initial Clinical Audit on the techniques, and the study seems to show that over 90% of patients significantly improved as a result of the treatments, and that two-thirds of patients (67%) reached a full recovery or close to that mark within one year. The average number of years with the illness was 10.5 years.
This paper has been submitted for peer review and will be published in a medical journal later in 2009. There was no control group - as this was simply an initial pilot to stimulate funding for a larger randomized, controlled trial.
FREE VIDEOS DETAILING THE HYPOTHESIS
If you are interested in finding out more about the hypothesis, you can view videos online at YouTube which are taken from the home-study programme and cover the entire hypothesis in depth:
Session 2: PART 1
http://www.youtube.com/watch?v=SEtyMHbf08U
Session 2: PART 2
http://www.youtube.com/watch?v=OYuOXdjaSJY
Session 2: PART 3
http://www.youtube.com/watch?v=8GKA3h56VWc
Session 2: PART 4
http://www.youtube.com/watch?v=JU-rOvhTZxA
Session 2: PART 5
http://www.youtube.com/watch?v=1YhI9eXkTic
Session 2: PART 6
http://www.youtube.com/watch?v=01srRrDqj54
postedbymermwellnesstrainresearchteam
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