Posted by TENA/DIAMOND on 3/26/2009, 3:16 am, in reply to "Re: Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of "
: Live Chat with Martin L. Pall, PhD – July 6,
: 2007: Professor of Biochemistry Explains
: Mechanisms of Chronic Fatigue Syndrome and
: Fibromyalgia & Suggested Protocol#4:
Q: Dr. Pall, is cod liver oil a good way to slow down the NO/ONOO- cycle?
Dr. Pall: Cod liver oil contains long chain omega 3 fatty acids, and these lower the induction of the inducible nitric oxide synthase. They should be helpful in this way.
* * * *
Q: Do you have an opinion on the use of malic acid for FM and/or CFS?
Dr. Pall: I suggest that magnesium malate may be the best form of magnesium to take.
* * * *
Q: How does NO/ONOO- theory compare to Dr. Paul Cheney's model of a deficiency of 3 main enzymes, presented on video from 2006?
Dr. Pall: Dr. Cheney and I have spent many hours on the phone discussing CFS. Our views on it are very similar. This is apparent from the comments he kindly made for my book. [Note: Dr. Cheney stated in his review, "A stunning expose on what is surely a central thesis of chronic, unexplained, and fatiguing illness; namely that oxidative stress mechanisms hold the key to any holistic viewpoint....This book could easily mark the end of the beginning of a more complete understanding of this complex field, which is a trillion dollar nightmare of human misery and bio-political inattention."]
* * * *
Q: What have other CFS and FM researchers said about your new ideas so far?
Dr. Pall: I got some great responses from the CFS people in England when I presented this recently. I have been invited back to keynote another CFS meeting in October.
* * * *
Q: Does this abnormal NO/ONOO- cycle chemistry have any connection to the theory of the abnormal methylation cycle that some Drs. are talking about? [Rich Van Konynenburg, PhD’s glutathione depletion-methylation cycle block theory of CFS.]
Dr. Pall: This methylation concept is a very different concept from the NO/ONOO- cycle. I do think that a number of the agents suggested by those discussing methylation will help to lower the NO/ONOO- cycle – so they may be useful for reasons that have nothing to do with methylation. In addition, the biochemistry involved in the methylation cycle is impacted by the NO/ONOO- cycle biochemistry. For example, the enzyme methionine synthase is inhibited by nitric oxide.
* * * *
Q: Comparing Dr. Rich Van Konynenburg’s methylation cycle theory & the OH/ONOO- cycle, which concept do you think holds most promise for CFS & FM patients, and why?
Dr. Pall: We have communicated on this. The NO/ONOO- cycle mechanism is very extensively documented in my book, which contains about 1,500 references to the scientific literature. I have also published 16 papers on this mechanism. It is also much more complete than is Rich’s proposal, and provides detailed explanations for many features of these illnesses that have never been explained previously.
* * * *
Q: I am on the Rich Van Konynenburg protocol. Can I combine yours for MCS with this?
Dr. Pall: There are a lot of overlaps between the two. I’d have to look at them in more detail to see if there any incompatibilities between them, but I suspect they are compatible.
* * * *
Q: Isn't peroxynitrite a radical scavenger, which could greatly disrupt the energy production in the mitochondria? Do you think Dr. Robert Suhadolnik's work on the RNase L antiviral pathway could be the trigger which chews up the messenger RNA as well as the viral RNA - could be what is causing the NO and peroxynitrite problem?
Dr. Pall: Peroxynitrite attacks multiple components of mitochondria, and this is an important part of the NO/ONOO- cycle, and also contributes to symptoms. I don’t think we know how the 37 kD RNase L is involved – at this point, we have a wide ranging explanation of CFS without involving this factor, but that does not mean it does not have a role.
* * * *
Q: Do you think a pharmaceutical company could make and patent a drug that would break the free radical cycle?
Dr. Pall: I think there are drugs that are helpful, and others may be developed in the future that may be more so – I talk about one possibility in my book that has substantial promise. But I think that the “magic bullet” approach to dealing with chronic diseases in general is dysfunctional.
* * * *
Q: Is it possible to repair the superoxide dismutase production in the body?
Dr. Pall: There is a lot of experimental work on what are known as “superoxide dismutase mimics” – relatively small molecules that get rid of superoxide. I don’t know what the prospects are for these being developed as effective drugs.
* * * *
Q: Dr. Pall, do you believe the pharmaceutical company industry will lobby the drug insurance companies to block funding for supplements, or do you expect the medical industry in general to embrace your system?
Dr. Pall: The lobbying has been going on vigorously for quite a while. You should look at Dr. Jerome Kassirer’s book entitled On the Take – it is very enlightening.
* * * *
Q: Do you think the NO/ONOO- protocol might change any over time?
Dr. Pall: I certainly hope so. I hope we will learn rapidly how to get an improved clinical response. And I think that many physicians and scientists will be involved in this process in the future, as they have been in the past.
* * * *
Closing Chat Remark:
Thank you, Dr. Pall, for all your hard work, and for helping those of us with MCS [and other unexplained illnesses] have real answers behind a perplexing illness that is "not all in our head." Bless you!
ProHealth also wishes to thank Dr. Pall - and all the patients, researchers, and advocates who participated so generously in this Live Chat Event. Hopefully the information exchanged here will help advance the work to find a cause and a cure.
____
* Dr. Pall's book, Explaining "Unexplained Illnesses": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Posttraumatic Stress Disorder, Gulf War Syndrome and Others (Haworth Press, May 2007), is available through the ProHealth bookstore.
Note: This information has not been evaluated by the FDA. It is not medical advice and is not meant to prevent, diagnose, treat, or cure any illness, condition, or disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.
TENA/DIAMOND
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