Posted by TENA/ DIAMOND on 1/2/2009, 4:12 pm
New :CFS
Subject: New CFS
Although there has been a theory saying viruses may have something to do with cfs & fms, I think this is first proof something is going on. I know I had bad case of the Flu before I got sick with cfs/fms...something to think about anyway..
Chronic Fatigue Syndrome is associated with chronic enterovirus infection of the stomach -
Source: Journal of Clinical Pathology, online Sep 13, 2007
by John K S Chia and Andrew Y Chia
ImmuneSupport. com
09-13-2007
Background and Aims: The aetiology for Chronic Fatigue Syndrome (CFS) remains elusive although enteroviruses have been implicated as one of the causes by a number of studies. Since most CFS patients have persistent or intermittent gastrointestinal (GI) symptoms, the presence of viral capsid protein 1 (VP1), enterovirus (EV) RNA and culturable virus in the stomach biopsy specimens of patients with CFS was evaluated. Methods: 165 consecutive patients with CFS underwent upper GI endoscopies and antrum biopsies. Immunoperoxidase staining was performed using EV-specific monoclonal antibody (mAb) or a control mAb specific for cytomegalovirus (CMV). RT-PCR ELISA was performed on RNA extracted from paraffin sections or samples preserved in RNA later. Biopsies from normal stomach and other gastric diseases served as controls. 75 samples were cultured for EV. Results: 135/165 (82%) biopsies stained positive for VP1 within parietal cells, whereas 7/34 (20%) of the controls stained positive (p(0.001). CMV mAb failed to stain any of the biopsy specimens. Biopsies taken from six patients at the onset of the CFS/abdominal symptoms, and 2 - 8 years later showed positive staining in the paired specimens. EV RNA was detected in 9/24 (37%) paraffin-embedded biopsy samples; 1/21 controls had detectable EV RNA (p,0.01); 1/3 patients had detectable EV RNA from two samples taken 4 years apart; 5 patient samples showed transient growth of non-cytopathic enteroviruses. Conclusion: Enterovirus VP1, RNA and non-cytopathic viruses were detected in the stomach biopsy specimens of CFS patients with chronic abdominal complaints. A significant subset of CFS patients may have a chronic, disseminated, non-cytolytic form of enteroviral infection, which could be diagnosed by stomach biopsy. A patent application is on file for the procedures described herein. [Note: The full text of this article is currently available for free at
http://press. psprings. co.uk/jcp/ september/ cp50054.pdf] Source: Journal of Clinical Pathology. 2007;online Sep 13:1–6. Published online ahead of print. Doi: 10.1136/jcp. 2007.050054, by Chia JKS, Chia AY. EV Med Research, Lomita, California, USA. [E-mail: evmed@sbcglobal. net ] This research is supported in part by an unrestricted research grant from Gilead Sciences. The paper was presented in part at the 8th international IACFS conference on Chronic Fatigue Syndrome, Fibromyalgia and other related illnesses, January 2007, in Fort Lauderdale, Florida.
POSTED BY ~Karma~
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