FM & CFIDS INFORMATION - WELLNESS TRAIN: 1/Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: 2/Response to Small Intestinal B

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1/Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: 2/Response to Small Intestinal B

Posted by MERM on 6/21/2008, 11:34 am

1/Restless Legs Syndrome in Patients with Irritable Bowel Syndrome:

Background: Since restless legs syndrome (RLS) occurs with fibromyalgia, a link between IBS, SIBO, and RLS was studied.

Methods: BS patients with abnormal lactulose breath tests received rifaximin 1,200 mg day(-1) for 10 days, followed by tegaserod 3 mg, long-term, and 1 month of zinc 220 mg day(-1) and once-daily probiotic (N = 11) or rifaximin monotherapy (N = 2). IBS symptom improvement was assessed after rifaximin. RLS symptoms, IBS symptoms, and overall IBS global improvement were assessed at last posttreatment visit: 8/10 patients were followed long-term (mean, 139 days; range, 54-450 days).

Results: Ten of 13 patients exhibited >/=80% improvement from baseline in RLS symptoms. Five maintained complete resolution of RLS symptoms. Global gastrointestinal symptom improvement was great (n = 6), moderate (n = 5), or mild (n = 2).

Conclusion: This study suggests that SIBO associated with IBS may be a factor in some RLS patients and SIBO therapy provides long-term RLS improvement.Weinstock LB, Fern SE, Duntley SP.

2/Response to Small Intestinal Bacterial Overgrowth Therapy

Background: Since restless legs syndrome (RLS) occurs with fibromyalgia, a link between IBS, SIBO, and RLS was studied.

Methods: BS patients with abnormal lactulose breath tests received rifaximin 1,200 mg day(-1) for 10 days, followed by tegaserod 3 mg, long-term, and 1 month of zinc 220 mg day(-1) and once-daily probiotic (N = 11) or rifaximin monotherapy (N = 2).

IBS symptom improvement was assessed after rifaximin.

RLS symptoms, IBS symptoms, and overall IBS global improvement were assessed at last posttreatment visit: 8/10 patients were followed long-term (mean, 139 days; range, 54-450 days).

Results: Ten of 13 patients exhibited >/=80% improvement from baseline in RLS symptoms. Five maintained complete resolution of RLS symptoms. Global gastrointestinal symptom improvement was great (n = 6), moderate (n = 5), or mild (n = 2).

Conclusion: This study suggests that SIBO associated with IBS may be a factor in some RLS patients and SIBO therapy provides long-term RLS improvement.

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1/Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: 2/Response to Small Intestinal B - MERM 6/21/2008, 11:34 am
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--Previous Message-- : 1/Restless Legs Syndrome in Patients with : Irritable Bowel Syndrome: : : Background: Since restless legs syndrome : (RLS) occurs with fibromyalgia, a link : between IBS, SIBO, and RLS was studied. : : Methods: BS patients with abnormal lactulose : breath tests received rifaximin 1,200 mg : day(-1) for 10 days, followed by tegaserod 3 : mg, long-term, and 1 month of zinc 220 mg : day(-1) and once-daily probiotic (N = 11) or : rifaximin monotherapy (N = 2). IBS symptom : improvement was assessed after rifaximin. : RLS symptoms, IBS symptoms, and overall IBS : global improvement were assessed at last : posttreatment visit: 8/10 patients were : followed long-term (mean, 139 days; range, : 54-450 days). : : Results: Ten of 13 patients exhibited : >/=80% improvement from baseline in RLS : symptoms. Five maintained complete : resolution of RLS symptoms. Global : gastrointestinal symptom improvement was : great (n = 6), moderate (n = 5), or mild (n : = 2). : : Conclusion: This study suggests that SIBO : associated with IBS may be a factor in some : RLS patients and SIBO therapy provides : long-term RLS improvement.Weinstock LB, Fern : SE, Duntley SP. : : 2/Response to Small Intestinal Bacterial : Overgrowth Therapy : : Background: Since restless legs syndrome : (RLS) occurs with fibromyalgia, a link : between IBS, SIBO, and RLS was studied. : : Methods: BS patients with abnormal lactulose : breath tests received rifaximin 1,200 mg : day(-1) for 10 days, followed by tegaserod 3 : mg, long-term, and 1 month of zinc 220 mg : day(-1) and once-daily probiotic (N = 11) or : rifaximin monotherapy (N = 2). : : IBS symptom improvement was assessed after : rifaximin. : : RLS symptoms, IBS symptoms, and overall IBS : global improvement were assessed at last : posttreatment visit: 8/10 patients were : followed long-term (mean, 139 days; range, : 54-450 days). : : Results: Ten of 13 patients exhibited : >/=80% improvement from baseline in RLS : symptoms. Five maintained complete : resolution of RLS symptoms. Global : gastrointestinal symptom improvement was : great (n = 6), moderate (n = 5), or mild (n : = 2). : : Conclusion: This study suggests that SIBO : associated with IBS may be a factor in some : RLS patients and SIBO therapy provides : long-term RLS improvement. : :

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