[ Post a Response | Trisomy 22 and Misc. 22 Interest Board ]
Posted by Ettina
on 3/1/2005, 12:37 pm, in reply to "Balanced 3:22? "
206.45.15.63
Balanced translocation means you have two abnormal chromosomes with exactly opposite abnormalities which cancel each other out. Basically the chromosomes traded some information. A person with a balanced translocation usually has no symptoms, unless the translocation disrupted a gene. However, their children could have problems. There are four possiblilities with 3;22 translocation, a chromosomally normal child who inherited the normal 22 and normal 3 chromosome, a child with partial monosomy 3 and partial trisomy 22, who inherited the abnormal 3 chromosome and normal 22 chromosome, a child with partial trisomy 22 and partial monosomy 3 who inherited the normal 3 chromosome and abnormal 22, or a child with the same balanced translocation, who will only have problems due to the translocation if their parent has problems due to it. Hope that helps.
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