From my experience with the admissions process (alhtough I did not apply to Nova), I think you should apply as soon as you can. My physics and calc courses occurred outside the 5 year threshold many schools publicize, but my program cared far more about how recently I had taken my biology credits, especially anatomy/physiology, and my GRE. I think you should strongly consider contacting the admissions department at Nova and ask them directly. My interactions with different departments were almost always warm and helpful.
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