[ Post a Response | 22q Deletion Interest Board ]
Posted by Amy --Previous Message--
on 10/20/2005, 9:57 pm, in reply to "is it usually hereditary"
64.108.150.2
Most cases (90%)of 22q are "de novo" (no family history). Researchers theorize that the deletion is occuring in an area of the gene that is more susceptible to problems - that's why such a large percentage of cases seem to come out of thin air.
When our daughter was diagosed eight years ago, the genetic counslers recommended that my husband and I both be tested as well just to confirm the de novo disagnosis. Neither of us has the deletion, so none of our other children even had to be tested.
We were told that our chances of having another child with the deletion were slightly higher than the general population since perhaps there was a group of eggs that were higher risk (if I'm understanding their explaination correctly-I'm still a little fuzzy on that - except to say if it happened once and they don't know why, then they can't say it won't happen again. But it's not likely.)
Once a person has the deletion, then they have a 50% chance of passing it on to their children. At that point it's literally a roll of the dice.
But from what you're saying, it sounds like you can rest easier - if you're not seeing a family history of symptoms, than chances are good if your son has the deletion it's a genetic fluke.
I hope you get some answers so you can continue on helping him.
Best of luck
: Hello! My son will be tested for 22q
: syndrome soon and I was wondering if
: this syndrome is hereditary? We
: have two children: our son has dev.
: delays (no heart defects), sensory
: issues, mild low muscle tone,
: strabismus and a very short attenion
: span. Our daughter has no delays or
: health concerns. Our family on both
: sides doesn't have any history of
: learning disabilities, MR, heart
: problems in either side of our
: families. Could we have a chance of
: having another child with this
: syndrome? The genetic appt isn't
: till January, so I'm very anxious to
: learn all I can. Thank you!
:
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